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Tumor Necrosis Factors Superfamily
TNF-related products from Covalab
LIGANDS :
RECEPTORS :
RANKL (CD254) is an osteoclast differentiation and activation factor and is involved in osteoclastogenesis, binding to RANK (CD265). It increases the ability of dendritic cells to stimulate naive T cell proliferation. It is an important regulator of interactions between T cells and dendritic cells and is involved in the regulation of the T cell-dependent immune response.
RANKL also plays an important role in the progression of breast cancer. Osteoprotegerin (OPG) is another receptor of RANK ligand produced by osteoblasts. It links to RANK to prevent RANK/RANKL-induced activation of osteoclasts.