Tumor Necrosis Factors Superfamily

TNF-related products from Covalab

 

LIGANDS :

RECEPTORS :

OX40L (CD134L / CD252) acts as a costimulator through its interaction with OX40 (CD134) on T cells, stimulating T cell activation, proliferation and cytokine production. It is expressed on antigen presenting cells including B cells, dendritic cells and mast cells. OX40 has a critical role in the maintenance of the immune response.

It was shown to prevent OX40L from reaching T cell receptors, thus reducing T cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off viruses successfully.