Covid-19 Products

ACCELERATE YOUR COVID-19 RESEARCH WITH OUR PRODUCTS CATALOG

 

covid19

 

 

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019 nCoV (2019 Novel Coronavirus) represents a pandemic threat that has been declared a public health emergency of international concern by WHO, mobilizing the actors of all the fields to find new means to fight against this virus, in particular in the field of research.

sars-cov-2

Covalab is making all the effort to help you in your research by offering wide range of tools such as specific proteins from SARS-Cov-2, antibodies or immunoassays involved in the metabolic pathways of infection, to accelerate the research, diagnostic and treatment of COVID-19.

2019 nCoV is an enveloped, single, and positive-stranded RNA virus. The virus encodes four major structural proteins that have played important roles in causing the infection (*): Spike protein (S protein), nucleocapsid protein (N protein), membrane protein (M protein), and small envelope protein (E protein) (Fig.1).

*: Fehr, A.R. & Perlman, S. 2015. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol 1282, 1-23

 

S protein is a large type I transmembrane protein, composed of two sub-units S1 and S2. S protein is essential for both host specificity and viral infectivity.

For viral entry, the S1 sub-unit binds via its RBD (Receptor Binding Domain) to the cellular receptor angiotensin-converting enzyme 2 (ACE2) and after cleavage by proteases (Furin and TMPRSS2), the active S2 sub-unit fuses to the viral membranes with the host cell membrane. The spike protein is reported to induce the neutralizing-antibody and T-cell responses, as well as protective immunity. The CoV spike (S) glycoprotein therefore represent the key target for vaccines, therapeutic antibodies, and diagnostics (*).

*: Hoffmann, M. et al. 2020. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell

 

SARS-Cov-2 can be triggered to fuse at either the plasma membrane or the endosomal membrane, and the route of entry is dependent on protease availability (Fig. 2).

sars viral cycle

 

The virus antigens are presented to the immune-system (APCs, macrophage, …) which in turn produce a range of pro- inflammatory "cytokines” (e.g. IL6, IFNα, IFNβ, IFNγ, IFNλ…) and TNF-α (*). In some cases, these cytokines proliferate and activate an uncontrolled and devastating pro-inflammatory response in the host.

* : Guo, Y.R. et al. 2020. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res 7, 11

tnf pathway

 

 

Coronavirus Research Products:

For all information about these following products, contact us at enquiries@covalab.com


RECOMBINANT PROTEINS:

 

Recombinant Spike Protein
Description   Packaging   Price

Spike - HEK / E.coli

Recombinant Spike (S) protein, amino acids 13-1273, C-terminal hexa-His-Tag (HEK cells) or N-terminal GST, C-terminal hexa-His-Tag (E.Coli).

  100 µg   449€
  1 mg   Contact us

Soluble Spike - HEK / E.coli

Recombinant soluble Spike (S) protein (ECD), amino acids 13-1213 C-terminal hexa-His-Tag (HEK cells) or N-terminal GST, C-terminal hexa-His-Tag (E.Coli).

  100 µg   449€
  1 mg   Contact us

S1-Subunit – HEK / E.coli

SARS CoV-2 recombinant Spike (S) protein S1-Subunit, amino acids 13-685, C-terminal hexa-His-Tag (HEK cells) or N-terminal GST, C-terminal hexa-His-Tag (E.Coli).

   100 µg   449€
S1-Subunit - Human Cells, tag-free   100 µg  

Contact us

RBD – HEK / E.Coli

SARS CoV-2 recombinant Spike (S) protein (receptor-binding domain, RBD), amino acids 319-541, C-terminal hexa-His-Tag (HEK cells) or N-terminal GST, C-terminal hexa-His-Tag (E.Coli).

   100 µg
   449€
  1 mg   Contact us

RBD, His Tag - Sf9 insect cells

   100 µg
  Contact us

S2-Subunit – HEK / E.coli

Recombinant Spike (S) protein S2-Subunit, amino acids 686-1273, C-terminal hexa-His-Tag (HEK cells) or N-terminal GST, C-terminal hexa-His-Tag (E.Coli).

  100 µg   449€
  1 mg   Contact us

Soluble S2-Subunit – HEK / E.coli

Recombinant Spike (S) protein (S2 ECD), amino acids 686-1213, C-terminal hexa-His-Tag (HEK cells) or N-terminal GST, C-terminal hexa-His-Tag (E.Coli).

  100 µg   449€
  1 mg   Contact us

Spike protein (ECD, His & Flag Tag) - Sf9 insect cells

  100 µg   Contact us

 

 

Recombinant E protein
 Description    Packaging   Price 

Protein E - HEK / E.coli

SARS CoV-2 recombinant E protein, amino acids 1-75, C-terminal hexa-His-Tag (HEK cells) or N-terminal GST, C-terminal hexa-His-Tag (E.Coli). 

   100 µg   449€ 
   1 mg   Contact us 

 

 

Recombinant N protein   
 Description   Packaging    Price 

Nucleocapsid (N) – HEK / E.coli

SARS CoV-2 recombinant N protein, amino acids 1-419, C-terminal hexa-His-Tag (HEK cells) or N-terminal GST, C-terminal hexa-His-Tag (E.Coli).

  100 µg   449€
  1 mg
  Contact us 

 Nucleocapsid (N) protein - E.coli

  100 µg
  Contact us 

 

 

Recombinant M protein    
Description    Packaging   Price 

Membrane protein (M) – HEK / E.Coli

SARS CoV-2 recombinant M protein, amino acids 1-222, C-terminal hexa-His-Tag (HEK cells) or N-terminal GST, C-terminal hexa-His-Tag (E.Coli).

  100 µg    449€ 
  1 mg   Contact us

 

 

Recombinant ACE-2 protein    
Description   Packaging    Price 

 ACE2 - HEK

Recombinant ACE2 protein (ACE2), amino acids 18-740, C-terminal hexa-His-Tag or N-terminal Flag Tag and hexa-his-Tag in C-term, HEK cells.

  100 µg   449€ 
  1 mg   Contact us

 ACE-2 Fc Chimera, Human

  100 µg
  Contact us

 

 


 

ANTIBODIES:

 

Spike (S) Protein
Description
  Species   #Catalog   Price
Monoclonal SARS‑CoV S1 Antibody   Human  
   Contact us
Polyclonal SARS‑CoV S1 Antibody   Human  
   Contact us
SARS Spike Protein Polyclonal Antibody Human   pab60443    449€
SARS Spike Protein Polyclonal Antibody
Human   pab60444    449€
SARS Spike Protein Polyclonal Antibody Human   pab60445    449€
SARS Spike Protein Polyclonal Antibody Human   pab60446    449€
SARS Spike Protein Polyclonal Antibody Human   pab60447    449€
 
Envelope (E) Protein
Description   Species   #Catalog   Price
SARS Envelope Protein Polyclonal Antibody Human   pab60448    449€
SARS Envelope Protein Polyclonal Antibody Human   pab60449    449€

 

 

Matrix (M) Protein
Description   Species   #Catalog   Price
SARS Matrix Protein Polyclonal Antibody Human   pab60450    449€
SARS Matrix Protein Polyclonal Antibody Human   pab60451    449€
 
Nucleocapsid (N) Protein
Description   Species   #Catalog   Price
Recombinant Monoclonal SARS‑CoV‑2 Nucleoprotein Antibody (clone 1A6, aa1‑419)   Human  
   Contact us
Polyclonal SARS‑CoV‑2 Nucleoprotein Antibody (250‑410 aa)   Human  
   Contact us

 

 

ACE2
Description   Species   #Catalog   Price
ACE2 (aa18-237) antibody (1G4) Human   mab72035    430€
Angiotensin Converting Enzyme 2 (ACE2) Human, Ms, Rat   mab60668    449€
Angiotensin Converting Enzyme 2 (ACE2) Human, Ms, Rat   pab60452    449€
Angiotensin Converting Enzyme 2 (ACE2) Human, Ms, Rat   pab60453    449€
Angiotensin Converting Enzyme 2 (ACE2) Human, Ms, Rat   pab60454    449€
Angiotensin Converting Enzyme 2 (ACE2) Human, Ms, Rat   pab60455    449€
 
TACE (ADAM17)
Description   Species   #Catalog   Price
ADAM17 (1F6) antibody Human   mab70671    490€
TACE/ADAM17 (C-Terminus) antibody Human, Ms, Rat
  pab60318    553€
ADAM17 (aa807-823) antibody   Human, Ms, Rat
  pab70244    500€
ADAM17 (C-Terminus) antibody Human   pab72207    430€
ADAM17 (C-Terminus) antibody Human   pab73146    430€

 

IRF3
Description   Species   #Catalog   Price
IRF3 antibody Human   pab70064    430€
IRF3 (C-Terminus) antibody Human, Ms   pab71533    430€
IRF3 (Internal) antibody Human   pab71534    430€
 
Cathepsin L
Description   Species   #Catalog   Price
CTSL1 / Cathepsin L antibody Human, Ms, Rat
  pab74978   430€ 
CTSL / Cathepsin L antibody Human, Ms, Rat
  pab75812    430€

 

 

Interleukin-1 Alpha (IL-1A)
Description   Species   #Catalog   Price
IL1A / IL-1 Alpha Antibody (clone 3A6F11) Human   mab72072    420€
 
Interleukin-1 Beta (IL-1B)
Description   Species   #Catalog   Price
IL-1b antibody (B-A15) Human   mab30201    440€

 

Interleukin-2 (IL-2)
Description   Species   #Catalog   Price
IL-2 antibody [FITC] (B-G5) Human   mab30371    212€
 
Interleukin-6 (IL-6)
Description   Species   #Catalog   Price
IL-6 antibody (B-E8) Human   mab30204     440€
IL-6 antibody (B-F6) Human, Ms   mab30205     440€
IL-6 Capture antibody (B-E8) Human   mab30276     863€
IL-6 Detection antibody [Biotin] (B-E4) Human   mab30407    448€
IL-6 antibody Rat   mab70404    430€
IL-6 (Internal) antibody Human   pab71514    430€
IL-6 (Internal) antibody Human   pab71515     430€

 

Interleukin-8 (IL-8)
Description   Species   #Catalog   Price
IL-8 antibody (B-K8) Human   mab30206     440€
IL-8 antibody Human   mab71308    430€
 
Interleukin-10 (IL-10)
Description   Species   #Catalog   Price
IL-10 antibody (B-T10) Human   mab30091     440€
IL-10 antibody (B-S10)     Human, Ms   mab30207     440€
IL-10 (JES5-2A5) antibody Ms   mab70381    430€

 

CD126
Description   Species   #Catalog   Price
CD126 Capture antibody (B-N12) Human   mab30283    863€
CD126 Detection antibody [Biotin] (B-R6) Human   mab30415    448€
 
Interleukin-17A (IL-17A)
Description   Species   #Catalog   Price
IL-17A antibody (B-B51)                Human   mab30095     440€
IL-17A antibody (B-A50) Human   mab30098    183€ 
IL-17A antibody (B-C49) Human   mab30099     440€
IL-17A Capture antibody (B-C49) Human   mab30293    863€

 

Interleukin-18 (IL-18)
Description   Species   #Catalog   Price
IL-18Ra antibody (B-E43) Human   mab30191    206€
IL-18Ra antibody (B-E43) Human   mab30192    206€
IL-18Rb antibody (B-B46) Human   mab30193    206€
IL-18 antibody Human   pab74955    430€
 
PYD domains-containing protein 3 (NLRP3)
Description   Species   #Catalog   Price
NLRP3 (Nalpy3-b ) antibody Human   mab71284   430€
NLRP3 (N-Terminus) antibody Human, Ms   pab71843   430€ 
NLRP3 (Internal) antibody Human   pab72167    430€

 

Tumor Necrosis Factor-alpha (TNFa) 
Description   Species   #Catalog   Price
TNFa antibody (B-F7) Human   mab30217    440€
TNFa Capture antibody (B-F7) Human   mab30281    863€
TNFa Detection antibody [Biotin] (B-C7) Human   mab30413    448€
 
C-C motif chemokine 2 (MCP1/CCL2)
Description   Species   #Catalog   Price
MCP1 antibody Human, Rat   pab50374    335€
MCP1 antibody Human, Ms, Rat   pab50375    335€

 

 


 

IMMUNOASSAYS:

 

TNF-α
Description   Species   #Catalog   Price
Human TNF alpha ELISA Set
Human   kit30110   From 315€
Human TNF alpha ELISpot Set (plate not included) Human   kit30111   From 315€
Human TNF alpha ELISpot Set (sterile plate) Human   kit30112   From 315€
Human TNF alpha ELISpot Set (non-sterile plate) Human   kit30143   From 315€
Human TNF alpha ELISA Kit (pre-coated) Human   kit30204   From 315€
Human TNF alpha ELISpot Kit (pre-coated) Human   kit30235   From 315€
Human TNF alpha ELISpot Pair Human   kit30256   770€ 
 
IL-6
Description   Species   #Catalog   Price
Human IL-6 ELISA Set Human   kit30102    From 315€
Human IL-6 ELISpot Set (plate not included) Human   kit30103    From 315€ 
Human IL-6 ELISpot Set (sterile plate) Human   kit30104    From 315€
Human IL-6 ELISpot Set (non-sterile plate) Human   kit30142   From 315€
Human IL-6 ELISA Kit (pre-coated) Human   kit30195   From 315€
Human IL-6 ELISpot Kit (pre-coated) Human   kit30233   From 315€

 

CD126
Description   Species   #Catalog   Price
Human CD126 ELISA Kit (pre-coated) Human    kit30153   From 378€
 
IFN-γ
Description   Species   #Catalog   Price
Human IFN gamma ELISA Set
Human   kit30012   From 315€
Human IFN gamma ELISpot Set (plate not included) Human   kit30013   From 315€
Human IFN gamma ELISpot Set (sterile plate) Human   kit30014   From 315€
Human IFN gamma ELISA Kit (pre-coated) Human   kit30172   From 315€
Human IFN gamma ELISpot Kit (pre-coated) Human   kit30222   From 315€
Human IFN gamma ELISpot Pair Human   kit30242   770€

 

 


 

PEPTIDES:

 

peptide library

 

Thanks to our expertise in the fields of peptide design, synthesis and modification, we provide a high-quality peptide synthesis service, including a wide range of chemical modifications.

In addition, we offer a specific peptide library for research on SARS-CoV-2 form crude, >70% to very hight purity (>98%).

 

Protein name Lenght Uniprot ID
SARS-CoV-2 Spike Glycoprotein 1 273 aa P0DTC2 
HCoV-229E Spike Glycoprotein 1 173 aa P15423
SARS-CoV-2 N 419 aa P0DTC9
SARS-CoV-2 E 75 aa P0DTC4
SARS-CoV-2 M 222 aa P0DTC5
SARS-CoV-2 ORF3a 275 aa P0DTC3
and many others...

 

Contact us for design and more information about peptide synthesis at enquiries@covalab.com.

All our team are available for all requests.

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