Hypoxia-related products from Covalab

Hypoxia signalling pathway

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Hypoxia refers to a deprivation of oxygen that can affect the body as a whole (generalised hypoxia) or a tissue (tissue hypoxia). Oxygen is critical for many biological process at the molecular, cellular and tissue levels 1. Low levels of oxygen have been linked to many pathological situations. Among them heart and brain ischemia-related diseases and cancer progression are particularly linked with perturbed oxygen signalling and metabolism 2.

An important and well characterised “master regulator” of the adaptive response to changes in the levels of available oxygen is hypoxia-inducible factor (HIF). Activation of the HIF transcription factor signalling cascade leads to extensive changes in gene expression, which allow cells, tissues and organisms to adapt to reduced oxygenation 3.


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Hypoxia signalling pathway brochure

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  • 1 - Wenger et al. Hypoxia, a Novel Inducer of Acute Phase Gene Expression in a Human Hepatoma Cell Line. J Biol Chem 270 : 27865-27870, 1995
  • 2 - Semenza G.L. Oxygen Sensing, Homeostasis, and Disease. N Engl J Med 365 : 537-547, 2011
  • 3 - Pugh et al. Regulation of angiogenesis by hypoxia: role of the HIF system. Nature Medicine 9 : 677 – 684, 2003
  • 4 - Tian et al. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 1997 Jan 1;11(1):72-82
  • 5 - Gu et al. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr. 1998;7(3):205-13
  • 6 - Hara et al. Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney:suppression of HIF-mediated gene expression by HIF-3alpha.Biochem Biophys Res Commun. 2001 Oct 5;287(4):808-13.