PI3K-Akt-mTOR pathway

Akt signalling in cancer

PI3K / AKT / mTOR signalling pathway

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Amongst the numerous pathways implicated in cancer development, the PI3K/AKT/mTOR signalling pathway is highly active in cancer cells. Mutation or amplification of the PI3-kinase or AKT genes, as well as loss of function of PTEN protein, result in the activation of the mTOR pathway, which is associated with a poor prognosis in cancer, and therapy resistance.

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PI3K / AKT / mTOR signalling pathway brochure

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