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Caspase-9 (I20) antibody
Caspase-9, CASP-9
Apoptotic protease Mch-6
Apoptotic protease-activating factor 3, APAF-3
ICE-like apoptotic protease 6, ICE-LAP6
Gene name: CASP9, MCH6
Apoptotic protease Mch-6
Apoptotic protease-activating factor 3, APAF-3
ICE-like apoptotic protease 6, ICE-LAP6
Gene name: CASP9, MCH6
As low as
$738.10
In stock
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00097776
Cell death signals are transduced by death domain-containing adapter molecules and members of the caspase family of proteases. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3, a protease responsible for proteolytic cleavage of many key proteins involved in apoptosis. Caspase-9 plays a central role in cell death induced by a wide variety of apoptosis inducers including TNFa , TRAIL, anti-CD95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.
| ID Covalab | pab60070 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Peptide corresponding to aa 299- 318 of human caspase-9 |
| Activity cross reaction | Reacts with full lengh human Caspase-9. |
| Species | Hu |
| Labelling | None |
| Form | Purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | Caspase-9 |
| Uniprot ID | P55211 |
| Gene ID | 842 |
| Applications | ICC, IF, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: ICC (2 µg/ml) WB (1 µg/ml) |
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