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GRAP2 antibody (UW40) [PE]
GRB2-related adapter protein 2
Adapter protein GRID
GRB-2-like protein (GRB2L)
GRBLG
GRBX
Grf40 adapter protein (Grf-40)
Growth factor receptor-binding protein
Hematopoietic cell-associated adapter protein GrpL
P38
Protein GADS
SH3-SH2-SH3 adapter Mona
Gene name: GRAP2, GADS, GRB2L, GRID
Adapter protein GRID
GRB-2-like protein (GRB2L)
GRBLG
GRBX
Grf40 adapter protein (Grf-40)
Growth factor receptor-binding protein
Hematopoietic cell-associated adapter protein GrpL
P38
Protein GADS
SH3-SH2-SH3 adapter Mona
Gene name: GRAP2, GADS, GRB2L, GRID
As low as
$617.60
In stock
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00118975
GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.
ID Covalab | mab21320 |
---|---|
Product type | Primary antibodies |
Clonality | Monoclonal antibody |
Clone | UW40 |
Isotype | IgG2a |
Raised in | Mouse |
Immunogen | The mouse monoclonal antibody UW40 recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells. |
Activity cross reaction | GST-fusion human GRAP2/GADS protein |
Species | Hu |
Labelling | PE |
Form | Purified |
Preservative | NaN3 15 mM |
Storage instructions | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. |
Target | GRAP2 |
Uniprot ID | O75791 |
Gene ID | 9402 |
Applications | FC |
Working dilutions | Optimal dilution should be determined by the end user. |
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