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Glucose Transporter GLUT4 antibody
Solute carrier family 2, facilitated glucose transporter member 4
Glucose transporter type 4, insulin-responsive (GLUT-4)
Gene name: SLC2A4, GLUT4
Glucose transporter type 4, insulin-responsive (GLUT-4)
Gene name: SLC2A4, GLUT4
As low as
$528.40
In stock
Ref
00096260
Glucose Transporter 4 (GLUT4/SLC2A4) is a member of a family of proteins that facilitate glucose transport. In response to insulin GLUT4 translocates from low density microsomes to the plasma membrane. Activation of phosphatidylinositol-3-OH kinase is required for this trafficking event but is not sufficient. Insulin resistant subjects with and without diabetes show abnormal accumulation of GLUT4 in a dense membrane compartment in muscle and adipocytes from which insulin is unable to recruit GLUT4 to the cell surface.
ID Covalab | pab52658 |
---|---|
Product type | Primary antibodies |
Clonality | Polyclonal antibody |
Raised in | Rabbit |
Immunogen | A synthetic peptide made to an internal portion of the human GLUT4 protein (between residues 480-509) |
Activity cross reaction | Reacts with human and mouse GLUT4 protein. May cross react with rat (100% sequence homology). |
Species | Hu, Ms, Rat |
Labelling | None |
Form | Antigen affinity purified |
Preservative | NaN3 0.05% |
Storage instructions | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
Target | Glucose Transporter GLUT4 |
Uniprot ID | P14672 |
Applications | ICC, IF, IHC, WB |
Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : - ICC : 1/100 - IF : 1/100 - IHC : 1/200 - WB : 0.5µg/ml |
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