Phospholipase C-zeta-1 (PLC-zeta-1) antibody

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1, PLCζ
Phosphoinositide phospholipase C-zeta-1
Phospholipase C-zeta-1, PLC-zeta-1
Testis-development protein NYD-SP27
Gene name: PLCZ1
As low as $323.40
In stock
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion.
More Information
ID Covalab pab0367-P
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide derived from internal part of PLC-zeta-1
Activity cross reaction Reacts with human PLC zeta protein.
No cross reaction
Species Hu
Labelling None
Form Purified (protein A)
Preservative None
Storage instructions Lyophilized powder stable for a minimum of 2 years at -20°C.
Store reconstituted antibodies at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target Phospholipase C-zeta-1
Uniprot ID Q86YW0
Applications ELISA, ICC, IF, IHC, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
IHC (10 µg/ml)
WB (10 µg/ml)
Publication * Hua R. et al. Hum Reprod. 2023 Mar. (IF, WB)
* Dai J. et al. Mol Hum Reprod. 2022 Jul 21:gaac028
* M Lv et al. Reprod Biol Endocrinol. 2022 Jan 3:20(1):5 (IF, Hu)
* Xin A et al. Science Advances. 2020 Sep 01 (WB, IF, Hu)
* Rahimizadeh P et al. Mol Reprod Dev. 2019 Nov 17
* Torra-Massana M et al. Hum Reprod. 2019 Jul 26. (WB, Hu)
* Khakpour S et al. Andrologia. 2019 March 15 (Hu)
* Tavalaee M et al. Reproductive BioMedicine Online. 2017 Dec
* Kamali-Dolat Abadi M et al. Cell J. 2016 Fall;18(3):438-45. (WB, Hu)
* Ferrer-Vaquer A et al. J Assist Reprod Genet. 2016 Jun,33(6):747-56. (WB)
* Aarabi M et al. Fertil Steril. 2014 Aug,102(2):440-7.
* Kashir J et al. Fertil Steril. 2013 Jan,99(1):107-17. (ICC, Hu)
* Aarabi M et al. PLoS One. 2012,7(3):e33496. (IHC, ICC / Ms, Hu)
* Kashir J et al. Reprod Biomed Online. 2011 Aug,23(2):263-7. (ICC, Hu)
* Young C et al. Fertil Steril. 2009 May,91(5 Suppl):2230-42.
* Grasa P et al. Hum Reprod. 2008 Nov,23(11):2513-22. (WB)
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