Kos1 antibody

Non-receptor tyrosine-protein kinase TNK1
Kinase of embryonic stem cells
Gene name: Tnk1, Kos1
As low as $528.40
In stock
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00099461
Kinase of embryonic stem cells (Kos1) is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Kos1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Kos1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
More Information
ID Covalab pab51805
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen C-terminal residues 421-434 [QNQVQSLPAGSAEP] of the 47 kDa mouse Kos1 / Tnk1 protein.
Activity cross reaction Reacts with mouse and human Kos1.
Species Hu, Ms
Labelling None
Form Purified
Preservative NaN3 0.02%
Storage instructions Short term storage at +4°C.
For extended periods store in aliquots at -20°C.
Antibodies are guaranteed for 6 month from date of receipt.
Target Kos1
Uniprot ID Q99ML2
Applications ICC, IF, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF (1:50 - 1:200)
WB (1:500 - 1:1000)
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