DcR2 antibody

Tumor necrosis factor receptor superfamily member 10D
Decoy receptor 2, DcR2
TNF-related apoptosis-inducing ligand receptor 4, TRAIL receptor 4, TRAIL-R4
TRAIL receptor with a truncated death domain
CD_antigen: CD264
Gene name: TNFRSF10D, DCR2, TRAILR4, TRUNDD
As low as $400.00
In stock
Ref
00097812
TRAIL/Apo2L is a new member of the TNF family and induces apoptosis in a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a "decoy receptor". Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAILR4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks an intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuates TRAIL induced apoptosis.
More Information
ID Covalab pab60106
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Peptide corresponding to aa 249-263 (intracellular) of human DcR2 precursor.
Activity cross reaction Reacts with human DcR2.
Species Hu
Labelling None
Form Purified
Preservative naN3 0.02%
Storage instructions Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.
Target DcR2
Uniprot ID Q9UBN6
Applications ICC, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
ICC (10 µg/ml)
WB (1 µg/ml)
Positive control HeLa cells
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