DcR1 (Extracellular Domain) antibody

Tumor necrosis factor receptor superfamily member 10C
Antagonist decoy receptor for TRAIL/Apo-2L
Decoy TRAIL receptor without death domain
Decoy receptor 1, DcR1
Lymphocyte inhibitor of TRAIL
TNF-related apoptosis-inducing ligand receptor 3, TRAIL receptor 3, TRAIL-R3
TRAIL receptor without an intracellular domain
CD_antigen: CD263
As low as $728.40
In stock
TRAIL/Apo2L is a member of the TNF family that induces apoptosis in a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has an extracellular TRAIL-binding domain but lacks an intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 does not induce apoptosis but attenuates TRAIL-induced apoptosis.
More Information
ID Covalab pab60105
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Peptide corresponding to aa 149-167 at the extracellular domain (ED) of human DcR1 precursor (accession no. AF012536).
Activity cross reaction Reacts with the extracellular domain of human, mouse and rat DcR1.
Species Hu, Ms, Rat
Labelling None
Form Purified
Preservative NaN3 0.02%
Storage instructions Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.
Target DcR1
Uniprot ID O14798
Applications ICC, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
ICC (10 µg/ml)
WB (1 µg/ml)
Positive control HeLa cells
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