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Ceramide Kinase antibody
Ceramide Kinase, hCERK
Acylsphingosine kinase
Lipid kinase 4, LK4
Gene name: CERK, KIAA1646
Acylsphingosine kinase
Lipid kinase 4, LK4
Gene name: CERK, KIAA1646
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00097779
Ceramide kinase (CERK), which phosphorylates ceramide to produce ceramide 1-phosphate (C1P), was first described as a Ca+2-stimulated lipid kinase that co-purified with brain synaptic vesicles. CERK activity has been reported in HL60 cells, mast cells, and neutrophils. CERK is involved in phagolysosome formation in plymorpho-nuclear leukocytes and also in liposome fusion. C1P has been reported to have mitogenic effects. More recently, C1P was found to induce arachidonic acid release and prostanoid synthesis.
| ID Covalab | pab60073 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | 20 amino acid peptide from N-terminal extracellular domain of human CERK |
| Activity cross reaction | Reacts with human Ceramide Kinase. Predicted to cross react with monkeys. |
| Species | Hu |
| Labelling | None |
| Form | Purified |
| Preservative | NaN3 0.1% |
| Storage instructions | Store at 4°C (short term) and -70°C (long-term) |
| Target | Ceramide Kinase |
| Uniprot ID | Q8TCT0 |
| Gene ID | 64781 |
| Applications | IHC |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: IHC (20 µg/ml) |
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