Bassoon, a 420kDa protein, is localized at presynaptic nerve terminals and appears to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The C-terminal regions of the polyglutamine domains are of interest since abnormal amplification of this region in some human proteins, such as Huntingtin, can cause late-onset neurodegeneration.
|Product type||Primary antibodies|
|Immunogen||Fusion protein corresponding to aa786-1041 (N-terminal) of human Bassoon (accession no. NM_003458.3).|
|Activity cross reaction||Reacts with human, mouse and rat Bassoon.|
|Species||Hu, Ms, Rat|
|Form||Purified (protein G)|
|Storage instructions||Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.|
|Applications||IF, IHC, WB|
|Working dilutions||Optimal dilution should be determined by the end user.
The following are guidelines only:
IF (1 - 10 µg/ml)
IHC (1 - 10 µg/ml)
WB (1 µg/ml)
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