APP (C-Terminus) antibody

Amyloid beta A4 protein
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide, CVAP
Protease nexin-II, PN-II
Gene name: APP, A4, AD1
As low as $738.10
In stock
Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The β-amyloid protein precursor (APP) is cleaved by β-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for γ-secretase to generate the 4 kD amyloid-β peptide which is deposited in the brain.
More Information
ID Covalab pab60022
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Peptide corresponding to aa 737-751 of human amyloid protein precursor (APP) or aa 85-99 of the C99 fragment generated by β- secretase cleavage. The sequences are identical to those of monkey, mouse, rat, chicken, and a variety of other species
Activity cross reaction Reacts with the human, mouse, and rat APP and the C99 fragment.
Species Hu, Ms, Rat
Labelling None
Form Purified
Preservative NaN3 0.02%
Storage instructions This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Target APP
Uniprot ID P05067
Applications WB
Working dilutions Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB 1:500-1:1,000
Positive control Mouse brain
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