A novel protein that causes chromatin condensation and DNA fragmentation has been designated Apoptosis Inducing Factor (AIF). AIF localizes in mitochondria and translocates to the nucleus when apoptosis is induced. This event is followed by the release of chytochrome c and caspase-9 from mitochondria. AIF is highly conserved between human and mouse and widely expressed in different cell types and tissues.
|Peptide corresponding to aa 593- 606 at the C-terminus of human AIF. This sequence is identical to those of mouse and rat AIF.
|Activity cross reaction
|Reacts with the C-terminus part of human AIF. Cross-reacts with mouse and rat protein.
|Hu, Ms, Rat
|Store in aliquots at -20°C.
Antibodies are guaranteed for 6 months from date of receipt.
|Apoptosis-inducing factor, AIF
|Optimal dilutions should be determined by the end user.
The following are guidelines only:
ICC 5 µg/ml
WB 0.5 - 2 µg/ml
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