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Nav1.8 Na+ Channel (S134-12) antibody
Sodium channel protein type 10 subunit alpha
Peripheral nerve sodium channel 3, PN3, hPN3
Sodium channel protein type X subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.8
gene name: SCN10A, FEPS2, Nav1.8, SNS
Peripheral nerve sodium channel 3, PN3, hPN3
Sodium channel protein type X subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.8
gene name: SCN10A, FEPS2, Nav1.8, SNS
As low as
$669.90
In stock
Ref
00096883
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Nav1.8 is a voltage-gated sodium channel that plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Since Nav1.8 is not present in cardiac muscle or neurons in the CNS, blockers of Nav1.8 will not directly affect those cells and can have less side effects than current pain medications.
ID Covalab | mab60370 |
---|---|
Product type | Primary antibodies |
Clonality | Monoclonal antibody |
Clone | S134-12 |
Isotype | IgG2a |
Raised in | Mouse |
Immunogen | Fusion protein, aa 1724-1956 (cytoplasmic C-terminus) of rat Nav1.8 (accession no. Q62968). |
Activity cross reaction | Reacts with human, mouse and rat Nav1.8. It does not cross-react with other Nav channels. |
Species | Hu, Ms, Rat |
Labelling | None |
Form | Purified (protein G) |
Preservative | NaN3 0.09% |
Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
Target | Nav1.8 Na+ Channel |
Uniprot ID | Q9Y5Y9 |
Gene ID | 6336 |
Applications | FC, ICC, IF, IHC, WB |
Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: IHC (0.1 - 1µg/ml) ICC/IF (1 - 10 µg/ml) WB (1 - 10 µg/ml) |
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