Nav1.8 Na+ Channel (S134-12) antibody

Sodium channel protein type 10 subunit alpha
Peripheral nerve sodium channel 3, PN3, hPN3
Sodium channel protein type X subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.8
gene name: SCN10A, FEPS2, Nav1.8, SNS
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Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Nav1.8 is a voltage-gated sodium channel that plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Since Nav1.8 is not present in cardiac muscle or neurons in the CNS, blockers of Nav1.8 will not directly affect those cells and can have less side effects than current pain medications.
More Information
ID Covalab mab60370
Product type Primary antibodies
Clonality Monoclonal antibody
Clone S134-12
Isotype IgG2a
Raised in Mouse
Immunogen Fusion protein, aa 1724-1956 (cytoplasmic C-terminus) of rat Nav1.8 (accession no. Q62968).
Activity cross reaction Reacts with human, mouse and rat Nav1.8. It does not cross-react with other Nav channels.
Species Hu, Ms, Rat
Labelling None
Form Purified (protein G)
Preservative NaN3 0.09%
Storage instructions Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.
Target Nav1.8 Na+ Channel
Uniprot ID Q9Y5Y9
Gene ID 6336
Applications FC, ICC, IF, IHC, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
IHC (0.1 - 1µg/ml)
ICC/IF (1 - 10 µg/ml)
WB (1 - 10 µg/ml)
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