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Hsp70/Hsc70 (BB70) antibody
Heat shock 70 kDa protein 1A/1B
Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP70.1/HSP70.2
Gene name: HSPA1A, HSPA1, HSX70, HSPA1B
Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP70.1/HSP70.2
Gene name: HSPA1A, HSPA1, HSX70, HSPA1B
As low as
$634.70
In stock
Ref
00096768
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
| ID Covalab | mab60255 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | BB70 |
| Isotype | IgG2a |
| Raised in | Mouse |
| Immunogen | Chicken Hsp70/Hsp90 complex |
| Activity cross reaction | Reacts with the inducible and constitutive forms of Hsp70 and does not cross-react with Hsp90. Detects 72 and 73 kDa proteins corresponding to the predicted molecular masses of Hsp70 and Hsc70, respectively, on immunoblots of human, mouse, rat, rabbit, monkey, hamster, guinea pig, dog, bovine, sheep, pig, chicken yeast, fish, and Xenopus samples. |
| Species | Chick, Fi, Hu, Ma, Ms, Xe, Ye |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | None |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt. |
| Target | Hsp70/Hsc70 |
| Uniprot ID | P08107 |
| Gene ID | 3304 |
| Applications | IHC, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: WB 1 µg/ml IHC 5 µg/ml |
| Positive control | Canine MDCK cell |
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