High MW Kininogen Heavy Chain (2B5) antibody

Kininogen-1
Alpha-2-thiol proteinase inhibitor
Fitzgerald factor
High molecular weight kininogen, HMWK
Williams-Fitzgerald-Flaujeac factor
Kininogen-1 heavy chain
Gene name: KNG1,
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00096740
High molecular weight kininogen (HMWK) is a circulating plasma protein which participates in the initiation of blood coagulation, and in the generation of the vasodilator bradykinin via the Kallikrein-kinin system. HMWK is inactive until it either adheres to binding proteins beneath an endothelium disrupted by injury, thereby initiating coagulation, or it binds to intact endothelial cells or platelets for functions other than coagulation. HMWK is an alpha-globulin with six functional domains. It circulates as a single-chain 626 amino acid polypeptide . The heavy chain contains domains 1, 2, and 3, the light chain, domains 5 and 6. Domain 4 links the heavy and light chains.
More Information
ID Covalab mab60227
Product type Primary antibodies
Clonality Monoclonal antibody
Clone 2B5
Isotype IgG1
Raised in Mouse
Immunogen Purified human high molecular weight kininogen.
Activity cross reaction Reacts with the common heavy chain (~64kDa) of human HMWK and can neutralize the inhibitory activity of HMWK on platelet calpain.
Species Hu
Labelling None
Form Purified
Preservative None
Target High MW Kininogen Heavy Chain
Uniprot ID P01042
Applications ELISA, FA, ICC, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
IFA (Coagulation, Neutralising)
WB (3 - 5 μg/ml)
Publication * Schmaier AH et al. J Biol Chem. 1987 Jan 25,262(3):1405-11.
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