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High MW Kininogen Heavy Chain (2B5) antibody
Kininogen-1
Alpha-2-thiol proteinase inhibitor
Fitzgerald factor
High molecular weight kininogen, HMWK
Williams-Fitzgerald-Flaujeac factor
Kininogen-1 heavy chain
Gene name: KNG1,
Alpha-2-thiol proteinase inhibitor
Fitzgerald factor
High molecular weight kininogen, HMWK
Williams-Fitzgerald-Flaujeac factor
Kininogen-1 heavy chain
Gene name: KNG1,
As low as
$842.60
In stock
Ref
00096740
High molecular weight kininogen (HMWK) is a circulating plasma protein which participates in the initiation of blood coagulation, and in the generation of the vasodilator bradykinin via the Kallikrein-kinin system. HMWK is inactive until it either adheres to binding proteins beneath an endothelium disrupted by injury, thereby initiating coagulation, or it binds to intact endothelial cells or platelets for functions other than coagulation. HMWK is an alpha-globulin with six functional domains. It circulates as a single-chain 626 amino acid polypeptide . The heavy chain contains domains 1, 2, and 3, the light chain, domains 5 and 6. Domain 4 links the heavy and light chains.
ID Covalab | mab60227 |
---|---|
Product type | Primary antibodies |
Clonality | Monoclonal antibody |
Clone | 2B5 |
Isotype | IgG1 |
Raised in | Mouse |
Immunogen | Purified human high molecular weight kininogen. |
Activity cross reaction | Reacts with the common heavy chain (~64kDa) of human HMWK and can neutralize the inhibitory activity of HMWK on platelet calpain. |
Species | Hu |
Labelling | None |
Form | Purified |
Preservative | None |
Target | High MW Kininogen Heavy Chain |
Uniprot ID | P01042 |
Applications | ELISA, FA, ICC, WB |
Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: IFA (Coagulation, Neutralising) WB (3 - 5 μg/ml) |
Publication | * Schmaier AH et al. J Biol Chem. 1987 Jan 25,262(3):1405-11. |
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