We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Glutamate NMDA Receptor NR3A/B Subunit (K35/40) antibody
Glutamate receptor ionotropic, NMDA 3A, GluN3A
N-methyl-D-aspartate receptor subtype 3A, NMDAR3A, NR3A
NMDAR-L
N-methyl-D-aspartate receptor subtype 3A, NMDAR3A, NR3A
NMDAR-L
As low as
$638.00
In stock
Ref
00096704
Two new subunits of the NMDA subtype of glutamate receptor (NMDAR) have been identified, NR3A and NR3B, with NR3B likely being the final member of the NMDAR family. These subunits show high sequence homology, although different distribution patterns: NR3B is expressed predominately in motor neurons, while NR3A is more widely distributed. When expressed in Xenopus oocytes, NR3A or NR3B assemble with NR1 to form excitatory glycine receptors that are unaffected by glutatmate.
| ID Covalab | mab60191 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | K35/40 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Fusion protein of NR3A aa sequence 780-914 from the extracellular IIIIV loop. |
| Activity cross reaction | Reacts with human Glutamate NMDA Receptor NR3A/B Subunit. Cross-reacts with mouse and rat protein. Do not cross-react with subunits NR1 or NR2A-D. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | None |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | Glutamate NMDA Receptor NR3A/B Subunit. |
| Uniprot ID | Q8TCU5 |
| Gene ID | 116443 |
| Applications | IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : IHC (1 - 10 µg/ml) WB (1 - 10 µg/ml) |
| Publication | Chatterton JE, et al. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature. 2002 Feb 14,415(6873):793-8. Wong HK, et al. Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain. J Comp Neurol. 2002 Sep 2,450(4):303-17 Sasaki YF, et al. Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons. J Neurophysiol. 2002 Apr,87(4):2052-63. Perez-Otano I, et al. Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. J Neurosci. 2001 Feb 15,21(4):1228-37 |
Write Your Own Review