Factor-Inhibiting HIF-1 (FIH) (FIH162C) antibody

Factor Inhibiting hypoxiainducible factor1
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00096680
FIH, Factor Inhibiting HIF-1 (hypoxiainducible factor), is an asparaginyl hydroxylase. FIH, in conjunction with VHL, represses HIF-1 transcriptional activity by disrupting the interaction of HIF-1 with the transcriptional coactivators CBP/p300, and by recruiting histone deacetylases. FIH activity is inhibited during hypoxia. Recent studies show that low nuclear expression of FIH is a prognostic indicator for poor overall survival in cases of clear cell renal cell carcinoma.
More Information
ID Covalab mab60167
Product type Primary antibodies
Clonality Monoclonal antibody
Clone FIH162C
Isotype IgG1
Raised in Mouse
Immunogen Recombinant full-length human FIH expressed in E. coli.
Activity cross reaction Reacts with human Factor-Inhibiting HIF-1 (FIH).
Species Hu
Labelling None
Form Purified (protein G)
Preservative 0,09% NaN3
Storage instructions Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.
Target Factor-Inhibiting HIF-1 (FIH)
Applications ICC, IF, IHC, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC (1 - 10 µg/ml)
IHC (1 - 10 µg/ml)
IF (1 - 10 µg/ml)
WB (1 - 10 µg/ml)
Publication Stolze IP, et al. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected]. J Biol Chem. 2004 Oct 8,279(41):42719-25.
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