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Factor-Inhibiting HIF-1 (FIH) (FIH162C) antibody
Factor Inhibiting hypoxiainducible factor1
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00096680
FIH, Factor Inhibiting HIF-1 (hypoxiainducible factor), is an asparaginyl hydroxylase. FIH, in conjunction with VHL, represses HIF-1 transcriptional activity by disrupting the interaction of HIF-1 with the transcriptional coactivators CBP/p300, and by recruiting histone deacetylases. FIH activity is inhibited during hypoxia. Recent studies show that low nuclear expression of FIH is a prognostic indicator for poor overall survival in cases of clear cell renal cell carcinoma.
| ID Covalab | mab60167 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | FIH162C |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Recombinant full-length human FIH expressed in E. coli. |
| Activity cross reaction | Reacts with human Factor-Inhibiting HIF-1 (FIH). |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | 0,09% NaN3 |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | Factor-Inhibiting HIF-1 (FIH) |
| Applications | ICC, IF, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ICC (1 - 10 µg/ml) IHC (1 - 10 µg/ml) IF (1 - 10 µg/ml) WB (1 - 10 µg/ml) |
| Publication | Stolze IP, et al. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected]. J Biol Chem. 2004 Oct 8,279(41):42719-25. |
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