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Factor XII Heavy Chain (B7C9) antibody
Coagulation factor XII (EC:3.4.21.38)
Hageman factor, HAF
Coagulation factor XIIa light chain
Beta-factor XIIa part 2
HAE3
HAEX
Gene name : F12
Hageman factor, HAF
Coagulation factor XIIa light chain
Beta-factor XIIa part 2
HAE3
HAEX
Gene name : F12
As low as
$748.00
In stock
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00096678
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. This single chain zymogen circulates in blood and is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain wich contains only a catalytic domain.
| ID Covalab | mab60165 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | B7C9 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Purified human Factor XII. |
| Activity cross reaction | Reacts with human Factor XII Heavy Chain (KD of 9.8nM) and partially blocks Factor XII activity. Suitable for coagulation assays. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | None |
| Storage instructions | Stable for at least one year at -20°C to -70°C. Avoid multiple freeze-thaw cycles. |
| Target | Factor XII Heavy Chain |
| Uniprot ID | P00748 |
| Gene ID | 2161 |
| Applications | ELISA, ICC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. |
| Publication | Pixley RA, et al. A monoclonal antibody recognizing an icosapeptide sequence in the heavy chain of human factor XII inhibits surface-catalyzed activation. J Biol Chem. 1987 Jul 25,262(21):10140-5. |
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