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ENL (3.1.1) antibody
Protein ENL
YEATS domain-containing protein 1
LTG19
YEATS1
Gene name : MLLT1
YEATS domain-containing protein 1
LTG19
YEATS1
Gene name : MLLT1
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$579.70
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00096663
The AF4 and ENL (Eleven nineteen Leukemia) protein families are the most frequent MLL fusion partners accounting for two-thirds of MLL-associated leukemia incidence. The ENL family includes ENL and AF9 and has structural homology to the yeast Anc1 protein. ENL is a nuclear protein that is capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells as well as in yeast. Deletion muta-genesis demonstrated that the minimal portion of ENL required for activation of transcription was localized to its C-terminal 90 amino acids. This region is highly conserved between ENL and AF9 and is retained in all Hrx-ENL and Hrx-AF9 fusion proteins. Thus, the leukemogenic contribution and transcriptional activation potential of ENL colocalize to its highly conserved carboxy terminus.
| ID Covalab | mab60150 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 3.1.1 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Maltose-binding fusion protein containing ENL amino acids 414-472 (Accession no. NP_005925). |
| Activity cross reaction | Reacts with human ENL. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | None |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | ENL |
| Uniprot ID | Q03111 |
| Gene ID | 4298 |
| Applications | WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : WB (1 - 5 µg/ml) |
| Publication | Rubnitz JE, et al. ENL, the gene fused with HRX int(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells. Blood. 1994 Sep 15,84(6):1747-52. Mueller D, et al. A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood. 2007 Dec 15,110(13):4445-54. Yokoyama A, et al. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell. 2010 Feb 17,17(2):198-212. |
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