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DOG1 (DOG1.1) antibody
Anoctamin 1, ANO1
Calcium activated chloride channel
Discovered on gastrointestinal stromal tumors protein 1
Oral cancer overexpressed protein 2, ORAOV2
Transmembrane protein 16A, TMEM16A
Tumor-amplified and overexpressed sequence 2, TAOS2
Gene name : ANO1
Calcium activated chloride channel
Discovered on gastrointestinal stromal tumors protein 1
Oral cancer overexpressed protein 2, ORAOV2
Transmembrane protein 16A, TMEM16A
Tumor-amplified and overexpressed sequence 2, TAOS2
Gene name : ANO1
As low as
$565.40
In stock
Ref
00096630
DOG1 (Discovered on GIST1), also known as TMEM16A and ANO1, has emerged in recent years as a promising biomarker for gastrointestinal stromal tumors (GIST). It was originally discovered through microarray expression profiling analysis as a gene that is highly expressed in GIST, and subsequent immunohistochemical studies have shown its use in its diagnosis. DOG1 antibodies are more sensitive than KIT antibodies in detecting tumors of gastric origin, tumors with epithelioid morphology, and tumors harboring PDGFRA mutation. DOG1 immunoreactivity is rarely observed in other mesenchymal and nonmesenchymal tumor types. These results support the use of DOG1 as a biomarker for GIST.
ID Covalab | mab60117 |
---|---|
Product type | Primary antibodies |
Clonality | Monoclonal antibody |
Clone | DOG1.1 |
Isotype | IgG1 |
Raised in | Mouse |
Immunogen | Synthetic peptide corresponding to aa 904-986 of human DOG1 (accession no. Q5XXA6). |
Activity cross reaction | Reacts with human DOG1. |
Species | Hu |
Labelling | None |
Form | Purified (protein G) |
Preservative | None |
Storage instructions | This antibody is stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
Target | DOG1 |
Uniprot ID | Q5XXA6 |
Gene ID | 55107 |
Applications | IHC |
Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : IHC (1 - 10 µg/ml) |
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