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DNMT3L (S-117-9) antibody
DNA (cytosine-5)-methyltransferase 3-like
Gene name : DNMT3L
Gene name : DNMT3L
As low as
$383.00
In stock
Ref
00096629
Methylation of DNA at cytosine residues is important in regulation of gene expression. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked to development of cancer.
Three families of mammalian DNA methyltransferase genes have been identified: DNMT1, DNMT2, and DNMT3. The DNMT3 family members, DNMT3a and DNMT3b, are strongly expressed in embryonic stem (ES) cells, but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Studies show that DNMT3L regulates the activity of DNMT3a and DNMT3b and stimulates their catalytic activities. DNMT3L has been linked specifically to the process of carcinogenesis through its role in nuclear programming.
Three families of mammalian DNA methyltransferase genes have been identified: DNMT1, DNMT2, and DNMT3. The DNMT3 family members, DNMT3a and DNMT3b, are strongly expressed in embryonic stem (ES) cells, but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Studies show that DNMT3L regulates the activity of DNMT3a and DNMT3b and stimulates their catalytic activities. DNMT3L has been linked specifically to the process of carcinogenesis through its role in nuclear programming.
| ID Covalab | mab60116 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | S-117-9 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Fusion protein, aa 1-387 of human DNMT3L (accession no. BAA95556). |
| Activity cross reaction | Reacts with human DNMT3L. It does not cross-react with DNMT3a or DNMT3b. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | 0,09% NaN3 |
| Storage instructions | This antibody is stable for at least one year at -20°C. Avoid repeated freezing and thawing. |
| Target | DNMT3L |
| Uniprot ID | Q9UJW3 |
| Gene ID | 29947 |
| Applications | ICC, IF, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ICC (0.1 - 1 µg/ml) IF (1 - 10 µg/ml) IHC (0.1 - 1 µg/ml) WB (1 - 10 µg/ml) |
| Positive control | Lysate of COS cells transiently transfected with Flag-tagged |
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