CENP-A (5A7-2E11) antibody

Histone H3-like centromeric protein A
Centromere autoantigen A
Centromere protein A, CENP-A
Gene name: CENPA
CenH3
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Replicated chromosomes include two kinetochores that control chromosome segregation during mitosis. Centromere Protein-A (CENP-A), a histone H3-like protein, contains a C-terminal H3-like domain which is required for centromere localization of CENP-A. It is essential for kinetochore targeting of CENP-C. In the presence of DNA, CENP-A forms an octameric complex with histones H2A, H2B, and H4. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on chromosomes.
More Information
ID Covalab mab60076
Product type Primary antibodies
Clonality Monoclonal antibody
Clone 5A7-2E11
Isotype IgG1
Raised in Mouse
Immunogen Synthetic peptide corresponding to a sequence within human CENP-A (accession no. NP_001035891.1).
Activity cross reaction Reacts with human CENP-A.
Species Hu
Labelling None
Form Purified (protein G)
Preservative NaN3 0.09%
Storage instructions Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.
Target CENP-A
Uniprot ID P49450
Gene ID 1058
Applications ELISA, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
WB 1:1000
Positive control U2OS cell lysate
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