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CENP-A (5A7-2E11) antibody
Histone H3-like centromeric protein A
Centromere autoantigen A
Centromere protein A, CENP-A
Gene name: CENPA
CenH3
Centromere autoantigen A
Centromere protein A, CENP-A
Gene name: CENPA
CenH3
As low as
$537.90
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00096589
Replicated chromosomes include two kinetochores that control chromosome segregation during mitosis. Centromere Protein-A (CENP-A), a histone H3-like protein, contains a C-terminal H3-like domain which is required for centromere localization of CENP-A. It is essential for kinetochore targeting of CENP-C. In the presence of DNA, CENP-A forms an octameric complex with histones H2A, H2B, and H4. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on chromosomes.
| ID Covalab | mab60076 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 5A7-2E11 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Synthetic peptide corresponding to a sequence within human CENP-A (accession no. NP_001035891.1). |
| Activity cross reaction | Reacts with human CENP-A. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | NaN3 0.09% |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | CENP-A |
| Uniprot ID | P49450 |
| Gene ID | 1058 |
| Applications | ELISA, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: WB 1:1000 |
| Positive control | U2OS cell lysate |
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