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Amyloid Beta 1-42 (Ab42.2) antibody
Amyloid beta A4 protein
ABPP
APPI, APP
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide, CVAP
PreA4
Protease nexin-II, PN-II
Beta-amyloid protein 42
Beta-APP42
Gene name: APP, A4, AD1
ABPP
APPI, APP
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide, CVAP
PreA4
Protease nexin-II, PN-II
Beta-amyloid protein 42
Beta-APP42
Gene name: APP, A4, AD1
As low as
$685.30
In stock
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00096543
Accumulation and aggregation of amyloid β (Aβ) in the brain is indicated as the trigger of a pathological cascade that causes Alzheimer disease (AD). The highly amyloidogenic 42-amino acid form of Aβ (Aβ42) and amino-terminally truncated forms of Aβ (Aβx-42) are the predominant species of Aβ typically found in diffuse and senile plaques within the AD brain. The relative levels of Aβ42 appear to be the key regulators of Aβ aggregation into amyloid; thus Aβ42 has been implicated as the initiating molecule in the pathogenesis of AD.
| ID Covalab | mab60030 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | Ab42.2 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Synthetic peptide corresponding to Aβ35-42. |
| Activity cross reaction | Reacts with human and mouse Aβx-42 |
| Species | Hu, Ms |
| Labelling | None |
| Form | Purified |
| Preservative | None |
| Storage instructions | Stable for at least one year at -20°C |
| Target | Amyloid Beta 1-42 |
| Uniprot ID | P05067 |
| Gene ID | 351 |
| Applications | ELISA, IF, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: 1 - 10 µg/ml |
| Publication | Levites Y et al. Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. FASEB J. 2006 Dec:20(14):2576-8. Levites Y et al. Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice. J Neurosci. 2006 Nov15:26(46):11923-8. Levites Y et al. Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest. 2006 Jan:116(1):193-201. |
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