Amyloid Beta 1-42 (Ab42.2) antibody

Amyloid beta A4 protein
ABPP
APPI, APP
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide, CVAP
PreA4
Protease nexin-II, PN-II
Beta-amyloid protein 42
Beta-APP42
Gene name: APP, A4, AD1
As low as $685.30
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00096543
Accumulation and aggregation of amyloid β (Aβ) in the brain is indicated as the trigger of a pathological cascade that causes Alzheimer disease (AD). The highly amyloidogenic 42-amino acid form of Aβ (Aβ42) and amino-terminally truncated forms of Aβ (Aβx-42) are the predominant species of Aβ typically found in diffuse and senile plaques within the AD brain. The relative levels of Aβ42 appear to be the key regulators of Aβ aggregation into amyloid; thus Aβ42 has been implicated as the initiating molecule in the pathogenesis of AD.
More Information
ID Covalab mab60030
Product type Primary antibodies
Clonality Monoclonal antibody
Clone Ab42.2
Isotype IgG1
Raised in Mouse
Immunogen Synthetic peptide corresponding to Aβ35-42.
Activity cross reaction Reacts with human and mouse Aβx-42
Species Hu, Ms
Labelling None
Form Purified
Preservative None
Storage instructions Stable for at least one year at -20°C
Target Amyloid Beta 1-42
Uniprot ID P05067
Gene ID 351
Applications ELISA, IF, IHC, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
1 - 10 µg/ml
Publication Levites Y et al. Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. FASEB J. 2006 Dec:20(14):2576-8.
Levites Y et al. Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice. J Neurosci. 2006 Nov15:26(46):11923-8.
Levites Y et al. Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest. 2006 Jan:116(1):193-201.
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