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p53 Capture antibody (B-F34)
Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
As low as
$1,265.80
In stock
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00037202
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.
ID Covalab | mab30288 |
---|---|
Product type | Primary antibodies |
Clonality | Monoclonal antibody |
Clone | B-F34 |
Isotype | IgG2b |
Raised in | Mouse |
Immunogen | Recombinant p53 protein |
Activity cross reaction | Reacts with wild type and mutant p53, the epitope is within residues 18-30 of human p53 |
Species | Hu |
Labelling | None |
Form | Purified |
Preservative | None |
Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt. |
Target | p53 |
Uniprot ID | P04637 |
Gene ID | 7157 |
Applications | ELISA-C |
Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ELISA-C 1 - 5 µg/ml |
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