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p53 antibody (B-P3)
Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
As low as
$664.20
In stock
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00036970
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
| ID Covalab | mab30056 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | B-P3 |
| Isotype | IgG2a |
| Raised in | Mouse |
| Immunogen | Recombinant p53 protein |
| Activity cross reaction | Reacts with wild type and mutant human p53, cross-react with p53 in other primates.The epitope is within residues 18-30 of human p53 |
| Species | Hu, Mk |
| Labelling | None |
| Form | Purified |
| Preservative | None |
| Storage instructions | Stable at +2 to 8°C for 12 months For longer storage, freeze aliquots |
| Target | p53 |
| Uniprot ID | P04637 |
| Gene ID | 7157 |
| Applications | ELISA, FC, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: WB (1:100 - 1:1000) IP (1 - 2 µg per 100-500 µg of total protein) IF (1:50 - 1:500) IHC (1:50 - 1:500) |
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