p53 antibody (B-P3)

Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
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00036970
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
More Information
ID Covalab mab30056
Product type Primary antibodies
Clonality Monoclonal antibody
Clone B-P3
Isotype IgG2a
Raised in Mouse
Immunogen Recombinant p53 protein
Activity cross reaction Reacts with wild type and mutant human p53, cross-react with p53 in other primates.The epitope is within residues 18-30 of human p53
Species Hu, Mk
Labelling None
Form Purified
Preservative None
Storage instructions Stable at +2 to 8°C for 12 months
For longer storage, freeze aliquots
Target p53
Uniprot ID P04637
Gene ID 7157
Applications ELISA, FC, IHC, IP, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only:
WB (1:100 - 1:1000)
IP (1 - 2 µg per 100-500 µg of total protein)
IF (1:50 - 1:500)
IHC (1:50 - 1:500)
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