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Nurr1 antibody
transcriptionally inducible nuclear receptor related 1
T-cell nuclear receptor NOT
Transcriptionally-inducible nuclear receptor
orphan nuclear receptor NR4A2
Orphan nuclear receptor NURR1
human homolog of nuclear receptor subfamily 4, group A, member 2
Gene name: NR4A2
T-cell nuclear receptor NOT
Transcriptionally-inducible nuclear receptor
orphan nuclear receptor NR4A2
Orphan nuclear receptor NURR1
human homolog of nuclear receptor subfamily 4, group A, member 2
Gene name: NR4A2
As low as
$528.40
In stock
Ref
00036429
The Nurr1 gene encodes a member of the steroid-thyroid hormone- retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's. Nurr1 is a stem cell marker and cooperates with PITX3 to promote terminal maturation of murine and human embryonic stem cell cultures to a midbrain dopamine neuron phenotype.In addition, Nurr1 is involved in the regulation of corticotropin-releasing hormone (CRH), which may be linked to and associated with rheumatoid arthritis.
| ID Covalab | pab51098 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Isotype | IgG |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide comprising residues 513-526 [TERHGLKEPKRVEE] of the human Nurr1 protein.Based on 100% sequence homology, this antibody is also expected to cross react with rat and mouse Nurr1. |
| Activity cross reaction | Reacts with human and rat Nurr1 |
| Species | Hu, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Nurr1 |
| Applications | IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : - IHC : 1/100 to 1/200 - WB : 1/1000 to 1/2000 |
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