MAPK1 / ERK antibody

Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1
Extracellular signal-regulated kinase 2, ERK-2
MAP kinase isoform p42, p42-MAPK
Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2
Gene name: MAPK1, ERK2, PRKM1, PRKM2
Out of stock
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.
More Information
ID Covalab mab71410
Product type Primary antibodies
Clonality Monoclonal antibody
Isotype IgG1 / Kappa
Raised in Mouse
Immunogen His-tagged recombinant human Erk2 protein purified from E. coli.
Activity cross reaction Reacts with human MAPK1 / ERK. Cross reacts with mouse and rat protein.
Species Hu, Ms, Rat
Labelling None
Form Purified
Preservative 0.03% NaN3
Storage instructions Long term: -20°C; Short term: -20°C
Target MAPK1 / ERK
Uniprot ID P28482
Gene ID 5594
Applications ELISA, IHC - P, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC-P (1:50),
WB (1:1000)
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