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BCL2 / Bcl-2 (11C5) antibody
B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2, PPP1R50
Gene name: BCL2
Gene name: BCL2
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00028372
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
| ID Covalab | mab71374 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 11C5 |
| Isotype | IgG2a / Kappa |
| Raised in | Mouse |
| Immunogen | Recombinant human protein purified from E. coli (His-Bcl-2). |
| Activity cross reaction | Reacts with human BCL2 / Bcl-2. |
| Species | Hu |
| Labelling | None |
| Form | Purified |
| Preservative | 0.03% NaN3 |
| Storage instructions | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Target | Apoptosis regulator Bcl-2 |
| Uniprot ID | P10415 |
| Gene ID | 596 |
| Applications | ELISA, IHC - P, IP, WB |
| Working dilutions | ELISA, IHC-P (1:100), IP, WB (1:2000) |
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