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ERK1 + ERK2 (aa330-379) antibody
Mitogen-activated protein kinase 3 & Mitogen-activated protein kinase 1
Extracellular signal-regulated kinase 1 & Extracellular signal-regulated kinase 2, ERK-1 & ERK-2, p44-MAPK & p42-MAPK
Gene name: MAPK3 & MAPK1
Extracellular signal-regulated kinase 1 & Extracellular signal-regulated kinase 2, ERK-1 & ERK-2, p44-MAPK & p42-MAPK
Gene name: MAPK3 & MAPK1
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00023226
erine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.
| ID Covalab | pab74077 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Isotype | IgG |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide from human p44/42 MAPK (aa330-379). |
| Activity cross reaction | Reacts with the human ERK1 & ERK2 (p44/42 MAPK ). Cross reacts with mouse and rat protein. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Target | ERK1 + ERK2 |
| Uniprot ID | P27361, P28482 |
| Applications | ELISA, IHC - P, WB |
| Working dilutions | ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500 - 1:1000) |
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