p53 (Acetyl-Lys379) antibody

Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
Out of stock
Ref
00023146
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.
More Information
ID Covalab pab73997
Product type Primary antibodies
Clonality Polyclonal antibody
Isotype IgG
Raised in Rabbit
Immunogen Synthetic peptide from human p53 around the acetylated site of Lys379.
Activity cross reaction Reacts with human TP53 / p53 (Acetyl-Lys379). Cross reacts with mouse and rat protein.
Species Hu, Ms, Rat
Labelling None
Form Antigen affinity purified
Preservative NaN3 0.02%
Storage instructions Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
Target p53 Acetyl-Lys379
Uniprot ID P04637
Gene ID 7157
Applications ELISA, ICC, IF, IHC - P
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
ELISA (1:10000), IF (1:100 - 1:500), IHC-P (5 µg/ml)
Positive control HeLa cells
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