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p53 (Acetyl-Lys379) antibody
Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Gene name: TP53, P53
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00023146
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription.
ID Covalab | pab73997 |
---|---|
Product type | Primary antibodies |
Clonality | Polyclonal antibody |
Isotype | IgG |
Raised in | Rabbit |
Immunogen | Synthetic peptide from human p53 around the acetylated site of Lys379. |
Activity cross reaction | Reacts with human TP53 / p53 (Acetyl-Lys379). Cross reacts with mouse and rat protein. |
Species | Hu, Ms, Rat |
Labelling | None |
Form | Antigen affinity purified |
Preservative | NaN3 0.02% |
Storage instructions | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Target | p53 Acetyl-Lys379 |
Uniprot ID | P04637 |
Gene ID | 7157 |
Applications | ELISA, ICC, IF, IHC - P |
Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ELISA (1:10000), IF (1:100 - 1:500), IHC-P (5 µg/ml) |
Positive control | HeLa cells |
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