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BCL2 / Bcl-2 (Internal) antibody
B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2, PPP1R50
Gene name: BCL2
Gene name: BCL2
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00023115
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
| ID Covalab | pab73966 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Isotype | IgG |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide from human BCL-2 (aa46-95). |
| Activity cross reaction | Reacts with human BCL2 / Bcl-2. Cross reacts with mouse and rat protein. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Target | Apoptosis regulator Bcl-2 |
| Uniprot ID | P10415 |
| Gene ID | 596 |
| Applications | ELISA, IF, IHC - P, WB |
| Working dilutions | ELISA (1:10000), IF (1:100 - 1:500), IHC-P (1:100), WB (1:500 - 1:1000) |
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