BCL2 / Bcl-2 (Internal) antibody

B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2, PPP1R50
Gene name: BCL2
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00023115
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
More Information
ID Covalab pab73966
Product type Primary antibodies
Clonality Polyclonal antibody
Isotype IgG
Raised in Rabbit
Immunogen Synthetic peptide from human BCL-2 (aa46-95).
Activity cross reaction Reacts with human BCL2 / Bcl-2. Cross reacts with mouse and rat protein.
Species Hu, Ms, Rat
Labelling None
Form Antigen affinity purified
Preservative NaN3 0.02%
Storage instructions Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
Target Apoptosis regulator Bcl-2
Uniprot ID P10415
Gene ID 596
Applications ELISA, IF, IHC - P, WB
Working dilutions ELISA (1:10000), IF (1:100 - 1:500), IHC-P (1:100), WB (1:500 - 1:1000)
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