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SIRT2 (C-Terminus) antibody
NAD-dependent protein deacetylase sirtuin-2
Regulatory protein SIR2 homolog 2
SIR2-like protein 2
Gene name: SIRT2, SIR2L, SIR2L2
Regulatory protein SIR2 homolog 2
SIR2-like protein 2
Gene name: SIRT2, SIR2L, SIR2L2
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00021485
NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins such as ACLY, PCK1 and RELA. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.
| ID Covalab | pab73212 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | 19 amino acid peptide near the carboxy terminus of the human SIRT2. |
| Activity cross reaction | Reacts with the C-terminus part of human SIRT2. Cross reacts with mouse and rat protein. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Target | SIRT2 |
| Uniprot ID | Q8IXJ6 |
| Gene ID | 22933 |
| Applications | ELISA, IHC - P, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : IHC-P (5 µg/ml), WB (1 - 2 µg/ml) |
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