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TIA1 (Internal) antibody
Nucleolysin TIA-1 isoform p40
RNA-binding protein TIA-1
T-cell-restricted intracellular antigen-1, TIA-1
TIA1 cytotoxic granule-associated RNA binding protein
p40-TIA-1
WDM
Gene name: TIA1
RNA-binding protein TIA-1
T-cell-restricted intracellular antigen-1, TIA-1
TIA1 cytotoxic granule-associated RNA binding protein
p40-TIA-1
WDM
Gene name: TIA1
Out of stock
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00021018
TIA-1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.
| ID Covalab | pab72947 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Goat |
| Immunogen | Synthetic peptide C-PKSTYESNTKQ from an internal region (aa189-199) of human TIA1. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Panda, Dog, Bat, Bovine, Rabbit, Opossum, Chicken, Xenopus (100%), Hamster (91%), Horse, Pig, Turkey, Pufferfish (82%). |
| Activity cross reaction | Reacts with TIA1 from human, monkey, mouse, rat, bat, bovine, dog, rabbit, chicken, Xenopus. This antibody is expected to recognize both reported isoforms (NP_071320.1 and NP_071505.1). |
| Species | Ca, Chick, Hu, Ms, Rat, Xe |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Store at -20°C. Minimize freezing and thawing. |
| Target | TIA1 |
| Uniprot ID | P31483 |
| Gene ID | 7072 |
| Applications | ELISA, ICC, IF, IHC - P, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: ELISA (1:128000) IHC-P (3.75 µg/ml) WB (0.1 - 0.3 µg/ml) |
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