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AXIN1 (C-Terminus) antibody
Axin-1
Axis inhibition protein 1 (hAxin)
AXIN1, AXIN, MGC52315
Axis inhibition protein 1 (hAxin)
AXIN1, AXIN, MGC52315
As low as
$628.00
In stock
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00020205
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway.
| ID Covalab | pab72528 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Goat |
| Immunogen | Synthetic peptide C-FEEKIIGKVEKVD from the C-terminus of human AXIN1 (NP_003493.1; NP_851393.1). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Gibbon (100%), Baboon (100%), Monkey (100%), Marmoset (100%) |
| Activity cross reaction | Reacts with the C-terminus part of human AXIN1. Cross reacts with bovine, canine, mouse and rat protein. This antibody is expected to recognise both reported isoforms. |
| Species | Bov, Ca, Hu, Ms, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Store at -20°C. Minimize freezing and thawing. |
| Target | AXIN1 |
| Accession Number | O15169 |
| Applications | ELISA, IHC - P |
| Working dilutions | ELISA (1:128000), IHC-P (3.75 µg/ml) |
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