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BACE1 (N-Terminus) antibody
Beta-secretase 1
Aspartyl protease 2 (ASP2) (Asp 2)
Beta-site amyloid precursor protein cleaving enzyme 1 (Beta-site APP cleaving enzyme 1)
Memapsin-2
Membrane-associated aspartic protease 2
BACE1, BACE, KIAA1149, APP beta-secretase, ASP2, Aspartylprotease 2, B-Secretase, Beta-site app cleaving enzyme, FLJ90568, HSPC104
Aspartyl protease 2 (ASP2) (Asp 2)
Beta-site amyloid precursor protein cleaving enzyme 1 (Beta-site APP cleaving enzyme 1)
Memapsin-2
Membrane-associated aspartic protease 2
BACE1, BACE, KIAA1149, APP beta-secretase, ASP2, Aspartylprotease 2, B-Secretase, Beta-site app cleaving enzyme, FLJ90568, HSPC104
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00015851
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
| ID Covalab | pab70380 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic 18 amino acid peptide from near N-terminus of human BACE1. Percent identity with other species by BLAST analysis: Human (100%), Gorilla (100%), Gibbon (100%), Monkey (100%), Marmoset (100%), Rat (100%), Mouse (94%), Bovine (94%), Hamster (9 ... |
| Activity cross reaction | Reacts with human BACE1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ZBTB47 (44%). |
| Species | Hu |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.1% |
| Storage instructions | Long term: -70°C, Short term: +4°C |
| Target | BACE1 |
| Uniprot ID | P56817 |
| Applications | IHC - P |
| Working dilutions | IHC - P (2.5 µg/ml) |
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