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AGT / Angiotensinogen (Internal) antibody
Angiotensinogen
Serpin A8
Gene name: AGT, SERPINA8
ANHU, FLJ92595, FLJ97926
Serpin A8
Gene name: AGT, SERPINA8
ANHU, FLJ92595, FLJ97926
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00015766
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.
ID Covalab | pab70295 |
---|---|
Product type | Primary antibodies |
Clonality | Polyclonal antibody |
Raised in | Rabbit |
Immunogen | Synthetic 13 amino acid peptide from internal region of human AGT / Angiotensinogen. Percent identity with other species by BLAST analysis: Human (100%), Chimpanzee (100%), Gorilla (100%), Orangutan (100%), Gibbon (100%), Monkey (100%), Marmoset (85%). |
Activity cross reaction | Reacts with human AGT / Angiotensinogen. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Species | Hu |
Labelling | None |
Form | Antigen affinity purified |
Preservative | NaN3 0.1% |
Storage instructions | Long term: -70°C; Short term: +4°C |
Target | AGT / Angiotensinogen |
Accession Number | P01019 |
Applications | IHC - P |
Working dilutions | IHC - P (2.5 - 5 µg/ml) |
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