AGT / Angiotensinogen (Internal) antibody

Angiotensinogen
Serpin A8
Gene name: AGT, SERPINA8
ANHU, FLJ92595, FLJ97926
Out of stock
Ref
00015766
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2.
More Information
ID Covalab pab70295
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic 13 amino acid peptide from internal region of human AGT / Angiotensinogen. Percent identity with other species by BLAST analysis: Human (100%), Chimpanzee (100%), Gorilla (100%), Orangutan (100%), Gibbon (100%), Monkey (100%), Marmoset (85%).
Activity cross reaction Reacts with human AGT / Angiotensinogen. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Species Hu
Labelling None
Form Antigen affinity purified
Preservative NaN3 0.1%
Storage instructions Long term: -70°C; Short term: +4°C
Target AGT / Angiotensinogen
Accession Number P01019
Applications IHC - P
Working dilutions IHC - P (2.5 - 5 µg/ml)
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