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PARK7 / DJ-1 (aa177-189) antibody
Protein DJ-1
Oncogene DJ1
Parkinson disease protein 7
Gene name: PARK7
Oncogene DJ1
Parkinson disease protein 7
Gene name: PARK7
Out of stock
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00015060
Park7/DJ-1 is one of several genes thought to cause autosomal-recessive early-onset parkinsonism. Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death.
| ID Covalab | pab70048 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide from human PARK7 / DJ-1 (aa177-189). |
| Activity cross reaction | Reacts with aa 177-189 of human PARK7 protein. Cross reacts with proteins from African green monkey, Chimpanzee and Zebrafish. |
| Species | Hu, Mk, Zfi |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.01% |
| Storage instructions | Store vial at -20 C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20 C or below. Avoid cycles of freezing and thawing. |
| Target | PARK7 / DJ-1 |
| Uniprot ID | Q99497 |
| Gene ID | 11315 |
| Applications | ELISA, IHC - P, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ELISA (1/10000 - 1/50000), IHC - P (2.5 µg/ml), WB (1/500 - 1/2000) |
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