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Cyclin D1 antibody (CD1.1)
G1/S-specific cyclin-D1
B-cell lymphoma 1 protein, BCL-1
BCL-1 oncogene
PRAD1 oncogene
Gene name: CCND1, BCL1, PRAD1
B-cell lymphoma 1 protein, BCL-1
BCL-1 oncogene
PRAD1 oncogene
Gene name: CCND1, BCL1, PRAD1
As low as
$415.30
In stock
Ref
00113493
Cyclin D1 antibody (CD1.1)
| ID Covalab | mab20321 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | CD1.1 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Purified cyclin D1 protein |
| Activity cross reaction | Reacts with human and rat cyclin D1. |
| Species | Hu, Rat |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | NaN3 15 mM |
| Storage instructions | Store at 2-8°C. Do not freeze. |
| Target | Cyclin D1 |
| Uniprot ID | P24385 |
| Gene ID | 595 |
| Applications | ELISA, FC, ICC, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: IHC (2 - 10 µg/ml) ICC (1 µg/ml) WB (1 µg/ml) IP (1 µg/ml) |
| Publication | * Diehl JA, et al. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev. 1997 Apr 15,11(8):957-72. * Diehl JA et al. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 1998 Nov15,12(22):3499-511. * Yang W et al. Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3 beta pathway and is antagonized by insulin-like growth factor 1. J Biol Chem. 2007 Feb 9,282(6):3799-808. * Mukherji A et al. GSK-3beta-dependent destabilization of cyclin D1 mediates replicational stress-induced arrest of cell cycle. FEBS Lett. 2008 Apr 2,582(7):1111-6. |
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