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ARPP-19 pS109 antibody
cAMP-regulated phosphoprotein 19
Gene name : arpp19
TEgg006a24.1
Gene name : arpp19
TEgg006a24.1
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00106522
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with ppp2r2d (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase
| ID Covalab | pab0966-IP |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from C terminal part of Xenopus tropicalis ARPP-19 containing a phosphoserine 109 |
| Activity cross reaction | Reacts with Xenopus tropicalis ARPP-19 pS109 |
| Species | Xe |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | None |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | ARPP-19 pS109 |
| Uniprot ID | Q28GU6 |
| Gene ID | 447957 |
| Applications | ELISA, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: WB 1:500 - 1:5000 |
| Publication | Dupré A. Phosphorylation of ARPP19 by protein kinase A prevents meiosis resumption in Xenopus oocytes. Nat Commun. 2014 Feb 14,5:3318. |
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