Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
|Product type||Primary antibodies|
|Immunogen||Synthetic peptide derived from C-terminal domain containing phospho-tyrosine 479 (pY479) of human CRMP-2|
|Activity cross reaction||Reacts with CRMP-2 pY479 from human, rat and mouse. No cross reactivity was detected with CRMP1, CRMP3, CRMP4 or CRMP5|
|Species||Hu, Ms, Rat|
|Form||Antigen affinity purified|
|Storage instructions||Store at -20°C
Antibodies are guaranteed for 6 month from date of receipt.
|Target||Collapsin response mediator protein 2 (CRMP-2)|
|Applications||ELISA, IHC, WB|
|Working dilutions||Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/50 to 1/200
- WB : 1/100 to 1/1 000
|Publication||Varrin-Doyer M et al. Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. J Biol Chem. 2009 May 8:284(19):13265-76.|
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