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ARHGEF2 pS122 antibody
Rho guanine nucleotide exchange factor 2
Guanine nucleotide exchange factor H1 (GEF-H1)
Microtubule-regulated Rho-GEF
Proliferating cell nucleolar antigen p40
Gene name: ARHGEF2, KIAA0651, LFP40
Guanine nucleotide exchange factor H1 (GEF-H1)
Microtubule-regulated Rho-GEF
Proliferating cell nucleolar antigen p40
Gene name: ARHGEF2, KIAA0651, LFP40
As low as
$511.50
In stock
Ref
00118047
Arhgef2 (Rho/Rac Guanine Nucleotide Exchange Factor 2), also called GEF-H1 is a Rho-GTPase GEF and a microtubule binding protein. Microtubule depolymerization causes detachment of Arhgef2 from microtubule cytoskeleton, released Arhgef2 activate Rho-GTPases, which modulate actin cytoskeleton. CDKL5 phosphorylates mouse Arhgef2 at Serine 122, in vitro, this site is conserved in human and rats.
| ID Covalab | pab01034-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic phospho-peptide surrounding Serine 122 from mouse ARHGEF2 |
| Activity cross reaction | Predicted to cross react with proteins from human ARHGEF2 phospho Serine 122 |
| Species | Ms, Rat |
| Labelling | None |
| Form | Purified (Antigen affinity purified) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | ARHGEF2 pS122 |
| Uniprot ID | Q92974 |
| Gene ID | 9181 |
| Applications | WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : WB (1:1000) |
| Publication | * Baltussen LL, et al. Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics. The EMBO journal, (2018) Dec 14;37(24) * Krendel M, et al. Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Nature cell biology 4, 294-301 (2002). |
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