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GRP78 antibody
Heat shock 70 kDa protein 5
Immunoglobulin heavy chain-binding protein (BiP)
Steroidogenesis-activator polypeptide
Gene name: Hspa5, Grp78
Immunoglobulin heavy chain-binding protein (BiP)
Steroidogenesis-activator polypeptide
Gene name: Hspa5, Grp78
As low as
$528.40
In stock
Ref
00101608
Categorized as stress response proteins, BiPs play an important role in folding and assembly of nascent proteins and in scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5- nontranslated region of BiP mRNA. BiP IRES activity increases when cells are heat-stressed. GRP78 is also important in maintenance of cell homeostasis and the prevention of apoptosis. Levels of GRP78 protein are reduced in brains of Alzheimer’s disease patients.
| ID Covalab | pab50363 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from C-term domain of the rat Grp78 protein. Within residues 600-654. |
| Activity cross reaction | Reacts with rat and mouse 78 kDa GRP-78 protein. Weakly cross reacts with human GRP-78. |
| Species | Ms, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.1% |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | 78 kDa glucose-regulated protein (GRP-78) |
| Uniprot ID | P06761 |
| Gene ID | 25617 |
| Applications | ICC, IF, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: WB 0.5 µg/ml ICC/IF 1:50 |
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