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Tetratricopeptide repeat protein 3 (TTC3/TPRD) antibody
Protein DCRR1
RING finger protein 105
TPR repeat protein D
Tetratricopeptide repeat protein 3, TPR repeat protein 3
Gene name: TTC3, DCRR1, RNF105, TPRD
RING finger protein 105
TPR repeat protein D
Tetratricopeptide repeat protein 3, TPR repeat protein 3
Gene name: TTC3, DCRR1, RNF105, TPRD
As low as
$306.10
In stock
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00014653
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
| ID Covalab | pab0532 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from Cter domain of human TTC3 |
| Activity cross reaction | Reacts with human E3 ubiquitin-protein ligase TTC3 |
| Species | Hu |
| Labelling | None |
| Form | Antiserum |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | E3 ubiquitin-protein ligase TTC3 |
| Uniprot ID | P53804 |
| Applications | ELISA, IF, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : IF (1:100 - 1:500) WB (1:500 - 1:5000) |
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