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Eukaryotic translation initiation factor 3 subunit E (eIF3e) (C Terminus) antibody
Eukaryotic translation initiation factor 3 subunit 6
Viral integration site protein INT-6 homolog
eIF-3 p48
Gene name : EIF3E, EIF3S6, INT6
Viral integration site protein INT-6 homolog
eIF-3 p48
Gene name : EIF3E, EIF3S6, INT6
As low as
$323.40
In stock
Ref
00012822
Belongs to the eIF-3 subunit E family. Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis.
| ID Covalab | pab0855-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from C terminal part of human eIF3e protein |
| Activity cross reaction | Reacts with human eIF3e protein. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Eukaryotic translation initiation factor 3 subunit E (eIF3e) |
| Uniprot ID | P60228 |
| Applications | IP, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only : - IP : 1/100 to 1/1000 - WB: 1/500 to 1/2000 |
| Publication | - Neusiedler J, Mocquet V, Limousin T, Ohlmann T, Morris C, Jalinot P. INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation. RNA. 2012 Jun;18(6):1163-77. - Morris C, Tomimatsu N, Richard DJ, Cluet D, Burma S, Khanna KK, Jalinot P. INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells. Cancer Res. 2012 Apr 15;72(8):2006-16. - Morris C, Wittmann J, Jäck HM, Jalinot P. Human INT6/eIF3e is required for nonsense-mediated mRNA decay. EMBO Rep. 2007 Jun;8(6):596-602. - Morris-Desbois C, Réty S, Ferro M, Garin J, Jalinot P. The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. J Biol Chem. 2001 Dec 7;276(49):45988-95 - Morris-Desbois C, Bochard V, Reynaud C, Jalinot P. Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. J Cell Sci. 1999 Oct;112 ( Pt 19):3331-42. |
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