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Otoferlin antibody (13A9)
Otoferlin
Fer-1-like protein 2
Gene name : OTOF, FER1L2
Fer-1-like protein 2
Gene name : OTOF, FER1L2
As low as
$306.10
In stock
Ref
00012796
Otoferlin is a key presynaptic SNARE protein involved in the control of neurotranmitter release and in the fusion of synaptic vesicle with the neuonal plasma membrane. Expressed in the synapses of cochlear inner hair cells
| ID Covalab | mab0053-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 13A9 |
| Isotype | IgG1 / Kappa |
| Raised in | Mouse |
| Immunogen | GST-fusion protein (fragment 1-395) |
| Activity cross reaction | Reacts with human, mouse and rat Otoferlin. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Otoferlin |
| Uniprot ID | Q9HC10 |
| Gene ID | 9381 |
| Applications | ELISA, FC, IF, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : IHC (1:100 - 1:500) IP (1:50 - 1:200) WB (1:200 - 1:1000) |
| Publication | * Roux et al. Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell. 2006 Oct 20:127(2):277-89. * Rouillon I. et al. Results of cochlear implantation in two children with mutations in the OTOF gene. Int J Pediatr Otorhinolaryngol. 2006 Apr:70(4):689-96. |
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