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CD3 antibody (OKT3)
T-cell surface glycoprotein CD3 epsilon chain
CD3
Gene : CD3e
CD3
Gene : CD3e
As low as
$242.00
In stock
Ref
00124674
The OKT3 monoclonal antibody targets an epitope on the epsilon subunit of the human CD3 complex. Known for its potent immunosuppressive properties, it has been used effectively to treat renal, heart, and liver allograft rejection. The CD3 complex, composed of gamma, delta, and epsilon subunits, is essential for TCR assembly, transport, and surface expression. CD3 is expressed on thymocytes during development and on all mature T cells. TCR crosslinking triggers intracellular signaling pathways leading to cell activation and proliferation.
| ID Covalab | mab0283-p |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | OKT3 |
| Isotype | IgG2a kappa |
| Raised in | Mouse |
| Immunogen | Human T lymphocytes or purified human T cell fractions expressing the CD3 complex. |
| Species | Human |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | T cell receptor-CD3-complex (specifically the CD3 epsilon chain) on the surface of circulating T cells |
| Uniprot ID | P07766 |
| Applications | FC, IF, IHC, WB |
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